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(-)-Gallocatechin gallate
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Catalog No. T3807Cas No. 4233-96-9
Alias Gallocatechin gallate, (-)-Gallocatechol gallate, (-)-gallocatechin-3-O-gallate
(-)-Gallocatechin gallate ((-)-gallocatechin-3-O-gallate) is the polyphenol isolated from tea, with cancer-preventive activities. (-)-Gallocatechin gallate decreases osteoclastogenesis at 20 microM.
(-)-Gallocatechin gallate
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Purity: 99.88%
Catalog No. T3807Alias Gallocatechin gallate, (-)-Gallocatechol gallate, (-)-gallocatechin-3-O-gallateCas No. 4233-96-9
(-)-Gallocatechin gallate ((-)-gallocatechin-3-O-gallate) is the polyphenol isolated from tea, with cancer-preventive activities. (-)-Gallocatechin gallate decreases osteoclastogenesis at 20 microM.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 5 mg | $40 | In Stock | In Stock | |
| 10 mg | $56 | In Stock | In Stock | |
| 25 mg | $123 | In Stock | In Stock | |
| 50 mg | $179 | In Stock | In Stock | |
| 100 mg | $268 | In Stock | In Stock | |
| 200 mg | $398 | - | In Stock | |
| 1 mL x 10 mM (in DMSO) | $44 | In Stock | In Stock |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Batch Information
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Purity:99.88%
Appearance:Solid
Color:White to Pink
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Product Introduction
(-)-Gallocatechin gallate AI Summary
(-)-Gallocatechin gallate exhibits a range of bioactivities, including the inhibition of key enzymes and proteases, antiviral activity, antidiabetic effects, antioxidant potential, and inhibition of metabolic pathways. It inhibits FabZ (IC50: 600.0 nM), FabI (IC50: 500.0 nM), and FabG (IC50: 1100.0 nM), and shows antiplasmodial activity against chloroquine-sensitive Plasmodium falciparum NF54 (IC50: 40100.0 nM) and chloroquine-resistant Plasmodium falciparum K1 (IC50: 6200.0 nM). It also inhibits yeast G6PD and G6PD-mediated NADPH production in mouse 3T3-L1 cells.
The compound demonstrates antiviral activity against HIV-1 (IC50: 4320.0 nM), Human herpesvirus 2, and HIV-2. It shows antioxidant activity, indicated by a deltaA value of 0.92 in an MTT assay and inhibition of Fe2+ ion-induced lipid peroxidation (log(%): 1.464). Additionally, (-)-Gallocatechin gallate inhibits lipid peroxidation in Sprague-Dawley rat heart mitochondria, with IC50 values of 14000.0 nM (FeSO4-induced oxygen consumption) and 8600.0 nM (malondialdehyde formation).
In metabolic and antidiabetic assays, it decreases fasting plasma triglycerides, free fatty acids, insulin, glucose levels, and body weight in Sprague-Dawley rats over 12 weeks. The compound inhibits HSP90 (IC50: 34000.0 nM), Zika virus NS2B-NS3 protease (IC50: 99000.0 nM), and human 20S proteasome chymotrypsin-like activity (IC50: 187.0 nM). It shows activity against SARS-CoV-2, reducing induced cytotoxicity with IC50 values greater than 20000.0 nM.
(-)-Gallocatechin gallate inhibits the formation of human alpha-synuclein filaments (IC50: 3600.0 nM) and the SARS-CoV 3C-like protease (IC50: 47000.0 nM, Ki: 25000.0 nM). It also inhibits dynein-related kinase 1A (DYRK1A) with an IC50 of 121.0 nM and the deacetylase activity of SIRT6 (IC50: 5400.0 nM, 85% inhibition at 100 uM concentration).
These diverse activities suggest that (-)-Gallocatechin gallate possesses potential therapeutic applications across various fields including antimicrobial, antiviral, antidiabetic, and neuroprotective treatments. Its log POW value of 0.12 indicates it is hydrophilic..
Note: Summary generated by AI. Data source: ChEMBL 
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | (-)-Gallocatechin gallate ((-)-gallocatechin-3-O-gallate) is the polyphenol isolated from tea, with cancer-preventive activities. (-)-Gallocatechin gallate decreases osteoclastogenesis at 20 microM. |
| Synonyms | Gallocatechin gallate, (-)-Gallocatechol gallate, (-)-gallocatechin-3-O-gallate |
| Molecular Weight | 458.37 |
| Formula | C22H18O11 |
| Cas No. | 4233-96-9 |
| Smiles | Oc1cc(O)c2C[C@@H](OC(=O)c3cc(O)c(O)c(O)c3)[C@@H](Oc2c1)c1cc(O)c(O)c(O)c1 |
| Relative Density. | 1.685 g/cm3 |
| Storage | keep away from direct sunlight,keep away from moisture | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 82 mg/mL (178.89 mM), Sonication is recommended. Chloroform, Dichloromethane, Ethyl Acetate, Acetone: Soluble | |||||||||||||||||||||||||||||||||||
| In Vivo Formulation | 10% DMSO+40% PEG300+5% Tween 80+45% Saline: 3.3 mg/mL (7.2 mM), Sonication is recommended. Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions. | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO
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Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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